Despite the different origins of #003-102 Ab (anti-NMDAR encephalitis patient) and ART5803 (GluN1-NTD immunized mouse), both antibodies bind to nearly identical epitopes on GluN1-NTD (Fig. 1f and Supplementary Table S2), suggesting the unique and strong immunogenicity of GluN1-NTD epitopes centered by Q357-V362 in mammals. This evidence concerns the gene GRIN1 and encephalitis.