These data are consistent with recent studies showing the contact between DSBs and NE invagination and the formation of microtubule/LINC-dependent Lamin-B-rich tubules in BRCA1-deficient breast cancer cells treated with etoposide, although in the latter case the formation of tubules was completely abrogated by nocodazole25,37,38. Here, BRCA1 is linked to breast carcinoma.