To validate the results obtained from the public databases, we performed immunohistochemical staining on the tissue microarray using two markers: c-Fos and MDK (Fig. S4B), and selected representative immunohistochemical staining results for these two markers in normal brain tissue, WHO grade II, WHO grade III, and GBM patients from the tissue microarray (Fig. S4A). This evidence concerns the gene FOS and glioblastoma.