Tissue microarray, immunofluorescence, and qPCR experiments confirmed that the M2 TAMs marker CD206 and the key molecular MDK expressed mainly in cancer cells are highly expressed in EGFRvIII-mutant GBM, suggesting that the MDK molecule is involved in the regulation of cancer cells on surrounding TAMs in EGFRvIII-mutant GBM. The gene discussed is MDK; the disease is cancer.