Analysis of the tissue microarray staining results showed that compared with the control group, c-Fos and MDK were highly expressed in gliomas; the expression levels of c-Fos and MDK in gliomas increased with the increase in WHO pathological grade; and c-Fos and MDK were significantly correlated in gliomas (Fig. S4C–E). The gene discussed is FOS; the disease is central nervous system cancer.