Further prognostic analysis showed that the prognosis of the high expression c-Fos and MDK group was worse than that of the low expression group in primary glioma patients; similarly, in primary GBM cases, the prognosis of the high expression c-Fos and MDK group was worse than that of the low expression group (Fig. S3D, H). The gene discussed is FOS; the disease is glioblastoma.