Pheochromocytoma cells (PC12), derived from rat adrenal medulla pheochromocytoma, are widely used in in vitro studies of neurological diseases.[18] In this study, we established a Bmal1 gene overexpression model in PC12 cells through lentiviral transfection, along with a negative control (NC) model. This evidence concerns the gene BMAL1 and hereditary pheochromocytoma-paraganglioma.