G6PD is a crucial erythrocyte enzyme that plays a vital role in preventing cellular damage from reactive oxidants by catalyzing the first reaction of the pentose phosphate pathway, generating nicotinamide adenine dinucleotide phosphate (NADPH) and ribose necessary for DNA synthesis.[4] Patients with G6PD deficiency cannot generate sufficient NADPH to protect themselves against oxidative stress, which leads to acute intravascular hemolysis. The gene discussed is G6PD; the disease is hemolysis.