Currently, many studies have shown that CHD3 gene variants can cause a variety of neurological and non-neurological abnormal phenotypes, but there are few reports related to epilepsy, and the case reported in this study is the first case in which CHD3 gene variants have been found in children with IS, and it is thought that the CHD3 gene may be a new gene for IS. The gene discussed is CHD3; the disease is epilepsy.