CHD3 and neurodevelopmental disorder: The group showed language impairment, neurodevelopmental disorders, and appearance abnormalities, but the epileptic phenotype was rare with only 1 case.[7] Functional validation indicated that CHD3 gene missense variants may cause neurodevelopmental disorders by interfering with the chromatin remodeling activity of the encoded protein through effects on ATPase activity and chromatin remodeling capacity.