There are several possible analgesic mechanisms of skin cooling, including reduction of metabolic, electrogenic, and ionic activities in neural tissue and activation of inhibitory neurons,[7,8] and activation of transient receptor potential melastatin 8 (TRPM8) is known to play an important role in the analgesic effect of skin cooling on neuropathic pain.[9] TRPM8 is a receptor that is sensitive to a non-noxious mild cooling temperature (<28 ̊C).[10,11] However, an analgesic effect of TRPM8 activation on propofol injection-induced pain has not been shown. This evidence concerns the gene TRPM8 and neuropathic pain.