CD40LG and chronic kidney disease: IgA nephropathy (IgAN), an immune-mediated glomerular disease, is the most common primary glomerulonephritis worldwide[1] and the leading cause of chronic kidney disease and end-stage renal disease (ESRD).[2] It is pathologically characterized by predominant IgA or IgA deposition in the mesangial area (common deposition of IgG, IgM, or complement C3) with mesangial hyperplasia.