IgA nephropathy (IgAN), an immune-mediated glomerular disease, is the most common primary glomerulonephritis worldwide[1] and the leading cause of chronic kidney disease and end-stage renal disease (ESRD).[2] It is pathologically characterized by predominant IgA or IgA deposition in the mesangial area (common deposition of IgG, IgM, or complement C3) with mesangial hyperplasia. This evidence concerns the gene C3 and chronic kidney disease.