Compared with the circulation of melanoma patients, the ratio of IgD− memory to initial B cells in the tumor increased, indicating that the humoral response in tumor microenvironment tends to be type-switching.[21] In addition, BAFF is related to the production of reactive IgG in tumor cells of melanoma patients.[22] Some studies have also shown that BAFF may be a serum marker related to uveal melanoma metastasis,[23] and BAFF is also a key driver of anti-tumor immune response induced by dendritic cells in melanoma host.[24] CD39 is an important immunosuppressive molecule. The gene discussed is ENTPD1; the disease is melanoma.