2019). Furthermore, syndecan‐4 was also found on EVs in gastric cancer (Poças et al. 2023). SDC‐1 and SDC‐4 are both known as ofCS‐carrying proteoglycans in cancer (Vidal‐Calvo et al. 2024; Bang‐Christensen et al. 2019; Seiler et al. 2017). Additionally, proteoglycans have been reported to be among the most common EV‐proteins on tdEVs from multiple cancers (Hoshino et al. 2020). This evidence concerns the gene SDC4 and cancer.