2019). Furthermore, syndecan‐4 was also found on EVs in gastric cancer (Poças et al. 2023). SDC‐1 and SDC‐4 are both known as ofCS‐carrying proteoglycans in cancer (Vidal‐Calvo et al. 2024; Bang‐Christensen et al. 2019; Seiler et al. 2017). Additionally, proteoglycans have been reported to be among the most common EV‐proteins on tdEVs from multiple cancers (Hoshino et al. 2020). The gene discussed is SDC1; the disease is cancer.