KEAP1 and chronic kidney disease: To assess the effect of genetic Nrf2 activation in proteinuric CKD with glomerular injury, we crossed Alport mice with Keap1 KD mice (Okawa et al, 2006; Taguchi et al, 2010) and examined kidney function and pathology in homozygous Keap1 KD-Alport (Fig 1A).