ASCL1 and glioblastoma: We and others have shown that preventing ASCL1 phosphorylation on SP sites, by mutating the serine residues to alanine, promoted neuronal differentiation [202], increased efficiency of fibroblast-to-neuron [160], and astrocyte-to-neuron reprograming [119,203], and enhanced differentiation of both neuroblastoma and glioblastoma cells [163,176].