ASCL1-mediated reprogramming to neurons has mainly used fibroblasts and glia as the cells of origin, but has also been demonstrated in hepatocytes, blood mononuclear cells, T cells and prostate cancer cells (tables 1 and 2) [10,70,109,110,112,123,124,126,133–136]. Here, ASCL1 is linked to Familial prostate cancer.