In one-sample MR analyses in CKB, the weighted genetic score was associated with reduced levels of BMI (β = −0.36, [−0.21, −0.50], p < 0.0001 [linear regression]) and all other measures of adiposity, in addition to a higher risk of lung cancer (OR = 1.51, [95% CI 1.13–2.01], p = 0.005 [logistic regression]) (Supplementary Table S5). Here, CKB is linked to lung cancer.