PIEZO1 and cancer: The dual nature of Piezo1 signalling is pivotal: activation of Piezo1 and downstream pathways are involved in promoting stiffness and tumour progression,36,41,55, 56, 57,75,82,85,86,93,102,103 while acute dynamic stimulation via FUS can trigger mitochondrial apoptotic pathways and induce cancer cell death.121, 122, 123 The distinct activation patterns likely drive these contrasting outcomes, where prolonged activation promotes survival and acute dynamic activation via FUS triggers apoptosis.