However, acute activation of these channels has also been demonstrated to induce cancer cell death.121, 122, 123 In a pancreatic cancer model, the knockdown of Piezo1 reduced the therapeutic effect of ultrasound and microbubbles in vivo, providing evidence that Piezo1 is required for FUS-induced apoptosis.121. This evidence concerns the gene PIEZO1 and pancreatic neoplasm.