PIEZO1 and central nervous system cancer: Numerous studies have highlighted that Piezo1 is highly expressed in brain samples from patients with high-grade gliomas compared to low-grade gliomas and normal brain tissue samples.66, 67, 68 Piezo1 expression levels increase proportionally to glioma grade, and in GBM, Piezo1 expression was shown to be upregulated (2.43-fold change) compared to normal brain tissue.66