The hierarchical relationship between Piezo1 activation and YAP/TAZ signalling has been explored in several cancer types, including cholangiocarcinoma (bile duct cancer)85 and cervical carcinoma cells (HeLa),86 where Piezo1 activation via its specific agonist Yoda 1 increases YAP translocation to the nucleus.85 The gene discussed is PIEZO1; the disease is cancer.