Among the multiple GR phosphorylation sites, serine 134 (S134)-mediated signalling triggers brain-derived neurotrophic factor (BDNF)-dependent positive neuroplasticity of glucocorticoids, learning and memory10 whereas S226-mediated signalling triggers negative plasticity of glucocorticoids and cognitive impairment.11 The gene discussed is NR3C1; the disease is Cognitive impairment.