Next, we examined whether KMT9 inhibition reducedproliferationof colorectal carcinoma cell lines, in which KMT9 was reported tocontrol stemness and growth of colon cancer. Compared to DMSO or the control compound 8-N, treatmentwith compound 8 strongly suppressed proliferation ofCaco-2 cells (Figure B,C), which was comparable to that observed upon KMT9 knockdown (Figure S5A). Here, HEMK2 is linked to malignant colon neoplasm.