Associations between NT-proBNP and AF have been reported widely in the literature alongside a consistently increased risk of stroke.24,25 Our previous work also indicated that people with lone AF continue to show evidence of subtle ventricular dysfunction and impaired myocardial energetics on cardiac magnetic resonance imaging/spectroscopy, despite normalization of rhythm ≈6 months postablation, consistent with the presence of a subclinical cardiomyopathy underpinning AF.22 This evidence concerns the gene NPPB and Stroke.