A meta-analysis by Nigussie E et al. in Ethiopia, which included patients with suspected dengue and febrile illness, estimated a pooled prevalence of dengue of 21% (4 studies, 1848 patients) for IgG, 9% (5 studies, 2255 patients) for IgM, and 48% (6 studies, 258 patients) for RNA [41]. This evidence concerns the gene CD40LG and dengue disease.