Simo FBN et al., in their systematic review and meta-analysis study, found that the prevalence of dengue in African resident fever populations was 24.8% for IgG (21 studies, 7050 patients), 10.8% for IgM (36 studies, 40251 patients), and 7.1% for RNA (21 studies, 15322 patients) [39]. Here, CD40LG is linked to dengue disease.