In the adjusted multivariate model, IL-4 (AOR: 1.007, 95% CI: 1.003–1.012, p = 0.0011) and lymphocyte count (AOR: 2.956, 95% CI: 1.186–7.364, p = 0.0199) remained independently associated with schistosomiasis. Here, IL4 is linked to schistosomiasis.