Aims of this study were to evaluate: a) serum levels of pro-inflammatory cytokines and D6-specific chemokines in women with GDM, compared to women with uncomplicated pregnancies matched for gestational age; b) the placental expression of the inflammasome NLRP-3, IL-1β and of decoy receptor D6 in GDM and healthy pregnant women. The gene discussed is NLRP3; the disease is gestational diabetes.