Upon adjusting the model with other clinical factors such as hypertension, diabetes, heart diseases and cerebrovascular diseases and histological types, also showed TC genotype of EPHX1 rs1051740 to be significantly associated with AKD in both co-dominant and over-dominant models, although the associations were no longer significant after FDR and Holm-Bonferroni corrections. This evidence concerns the gene EPHX1 and hypertensive disorder.