ABCA1 and atherosclerosis: These data collectively demonstrate that therapeutic Listerin overexpression attenuated the aortic lesion area in WD-induced atherosclerosis by ubiquitinating ABCA1 at lysine residues K1884 and K1957 to stabilize and upregulate ABCA1 expression, thereby establishing ABCA1 as the critical mediator of Listerin’s atheroprotective effects.