These data collectively demonstrate that therapeutic Listerin overexpression attenuated the aortic lesion area in WD-induced atherosclerosis by ubiquitinating ABCA1 at lysine residues K1884 and K1957 to stabilize and upregulate ABCA1 expression, thereby establishing ABCA1 as the critical mediator of Listerin’s atheroprotective effects. The gene discussed is LTN1; the disease is atherosclerosis.