In a further examination of the role of Listerin in atherosclerosis, we conducted a series of molecular biology experiments and found that Listerin could bind to ABCA1 to catalyze its K63-linked ubiquitination at Lys1884 and Lys1957, which inhibited lysosomal degradation via the ESCRT/lysosome pathway. The gene discussed is ABCA1; the disease is atherosclerosis.