Adding to the level of diagnostic complexity, certain sarcomas that may occur in the oral and maxillofacial region can also show frank epithelial differentiation, for example synovial sarcoma [54, 55], or may demonstrate aberrant immunohistochemical expression of epithelial markers, i.e., pancytokeratins and EMA, such as frequently observed in epithelioid sarcoma [46, 47, 56, 57], epithelioid variant of angiosarcoma [58–60], adamantinoma-like Ewing sarcoma [61], and TFCP2-rearranged [62–69] and alveolar rhabdomyosarcomas [70]. The gene discussed is TFCP2; the disease is synovial sarcoma.