Virtually all examples of TFCP2-rearranged rhabdomyosarcoma are diffusely positive for pancytokeratins, e.g., AE1/AE3, OSCAR, MNF116, and desmin, as well as myogenin and/or MYOD1, with MYOD1 showing higher sensitivity. Here, TFCP2 is linked to rhabdomyosarcoma.