TNF and lobular neoplasia: For example, bioinformatics analyses have shown that ORM1 is differentially expressed in bone marrow from patients with immune thrombocytopenia, and is involved in the activation of immune functions and the TNF-α signaling pathway.16 ORM1 has also been identified as a potential biomarker for distinguishing between latent and active tuberculosis.17 Additionally, ORM1 has been proposed as a novel biomarker for early detection of LN.7 Collectively, these reports suggest that ORM1 expression is elevated in LN.