In cell signaling networks, GSK3β resides at the nexus of multiple pathways involved in CKD, including mitochondria permeability transition (MPT), cytoskeletal organization, development control, insulin signaling pathway, canonical wingless (Wnt) pathway, NF-κB pathway, and the NF-E2-related factor 2 (Nrf2) antioxidant response signaling. The gene discussed is INS; the disease is chronic kidney disease.