We found that malignant epithelium of M1/M2/M3/M4 exhibited high expression levels of epithelium differentiation-related genes, such as PHGR1 and KRT20 (Figure 2C), whereas M5/M6 or H. pylori infection-associated GC samples exhibited high expression levels of inflammation-related genes, such as CXCL1/2/3/8, S100A9, S100P, and EMT signature, such as SPARC and VIM (Figure 2C and D). This evidence concerns the gene SPARC and gastric cancer.