Further enrichment analysis revealed that iCAF enriched chemokines, TGFβ, ECM, IL6 pathway, PDGFRA pathway, inflammatory response, hypoxia, tumor angiogenesis, and VEGF signaling pathway (Figure 6F), which are crucial for tumor progression, metastasis, and immune escape (Nishina et al., 2021). This evidence concerns the gene IL6 and neoplasm.