Furthermore, gene set variation analysis (GSVA) of upregulated genes revealed that TREM2_TAMs were enriched for PD1 signaling, innate immune system, and GC chemosensitivity, whereas Angio-TAMs were enriched for tumor angiogenesis, chemokines, HIF, VEGF pathway, and ECM organization involved in promoting the development of vascular and hypoxic tumors (Figure 5H). Here, PDCD1 is linked to neoplasm.