Collectively, we found that HpGC and ex-HpGC exhibits high expression levels of NECTIN2, PVR, and its target TIGIT, which may participate in immune escape in GC, indicated that blockade of TIGIT-NECTIN or TIGIT-PVR axes may be a promising immunotherapy modality for H. pylori infection-associated GC. Here, NECTIN1 is linked to gastric cancer.