Recent research displayed that block of placental growth factor (PIGF), a member of the vascular endothelial growth factor, could inactive CAFs and reduce the deposition of fibrosis-associated collagen and desmoplasia in pancreatic cancer TME, which could improve survival rate of murine pancreatic ductal adenocarcinoma (PDAC) model. The gene discussed is VEGFA; the disease is familial pancreatic carcinoma.