reported increased complex I + II linked oxidative capacity, maximal oxidative capacity and increased complex IV capacity in subjects with obesity and fatty liver compared to controls and that enhanced PBMC mitochondrial respiration positively associated with fatty liver scores, fasting insulin, HOMA‐IR and inflammatory markers (CRP, TNFa and IL‐6).20 This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.