In liver cancer, overexpression of the HGF/c‐Met pathway leads to excessive HGF secretion by mesenchymal cells, synergising with pathways such as PI3K/Akt/mTOR [149], MAPK/ERK [150], and Rho GTPases [151] to promote tumour proliferation, remodel the cytoskeleton, and facilitate metastasis. This evidence concerns the gene PIK3CA and neoplasm.