In hepatocellular carcinoma, high expression of phosphoenolpyruvate carboxykinase 1 (PCK1) accelerates the transition of the cell cycle from the G1 phase to the S phase under low glucose conditions by activating the CDK/Rb/E2F pathway, promoting the growth and division of liver cancer cells [65]. This evidence concerns the gene PCK1 and hepatocellular carcinoma.