Through a combination of in silico analyses, in vitro experiments, and functional genomics approaches, we identified the SNP rs2863002 as a regulatory variant within HSD17B12, a gene implicated in various cancer types.[30, 31, 32] Our comprehensive investigation reveals how this variant influences HSD17B12 expression, thereby impacting lipid metabolism and oncogenesis in neuroblastoma. Here, HSD17B12 is linked to cancer.