Additionally, we silenced GATA3 by siRNA transient transfection in neuroblastoma cell lines to mimic GATA3 binding impairment, and observed a concomitant increase in HSD17B12 expression (Figure 3I), thereby confirming the negative regulatory relationship and indicating that GATA3 functions as a transcriptional repressor for HSD17B12 expression. This evidence concerns the gene GATA3 and neuroblastoma.