Of particular significance is the interaction with GATA3, a critical player in sympathetic nervous system development and neuroblastoma cell identity.[37] Of note, it has been documented that GATA3 can act as either an activator or repressor of its target genes.[38] Our results suggest that the C risk allele of rs2863002 alters a GATA3 binding motif, reducing its binding affinity and leading to increased HSD17B12 expression. Here, GATA3 is linked to neuroblastoma.