HSD17B12 encodes for an enzyme crucial in the elongation of long‐chain fatty acids (LCFAs), a process occurring on the membranes of the endoplasmic reticulum.[35] To elucidate its biological role in neuroblastoma pathogenesis, we examined HSD17B12 function in lipid metabolism within this pediatric cancer. The gene discussed is HSD17B12; the disease is cancer.