To determine whether USP8 or AKT inhibitor could be used to treat MDA5‐induced autoimmunity, we generated Ifih1gs/+ (gs/+) mice via CRISPR editing (Figure7A,B) and found that the percentage of gs/+ mice was reduced from 47.1% (8 out of 17) of 2‐week‐old gs/+ embryos to 30.3% (10 out of 33) of 3‐week‐old gs/+ mice (Figure 7C). This evidence concerns the gene USP8 and Autoimmunity.