Importantly, inhibition of USP8 or AKT can effectively suppress MDA5‐induced autoimmunity in Aicardi–Goutières syndrome (AGS) mice and anti‐MDA5‐positive dermatomyositis (DM)/systemic lupus erythematosus (SLE) patient cells. This evidence concerns the gene IFIH1 and Aicardi-Goutières syndrome.