We then examined the association between USP8 and MDA5 and found that USP8 specifically interacted with MDA5 but not with other related proteins, such as RIG‐I (Figure 1F; Figure S1E, Supporting Information), and that their association was potentiated after EMCV infection, but not Poly(I:C) HMW (Figure 1G; Figure S1F, Supporting Information). Here, RIGI is linked to infection.