It has emerged as a key therapeutic target for HCC.<h4>Objective</h4>This study employs bibliometric analysis to examine literature published between 2000 and 2024, aiming to explore the critical roles of TGF-β in HCC and provide a theoretical foundation for future research.<h4>Methods</h4>This study utilized the Web of Science Core Collection (WoSCC) database to analyze publications from January 1, 2000, to October 16, 2024. This evidence concerns the gene TGFB1 and hepatocellular carcinoma.