Keyword analysis revealed that recent research (2020-2024) has focused on metabolic regulation, the tumor immune microenvironment, and targeted therapies related to the TGF-β signaling pathway in HCC.<h4>Conclusion</h4>This study highlights the publication landscape, research trends, and hotspots of TGF- β-related HCC research from 2000 to 2024, providing valuable insights and a theoretical basis for future studies in this critical field. Here, TGFB1 is linked to hepatocellular carcinoma.