Furthermore, targeted next‐generation sequencing (NGS) analysis of two MPE samples, one harboring the KRAS G12A mutation and a second harboring the EGFR exon 19 Glu746‐Ala750 deletion, revealed an increase in the mutated allele frequency following CD45+ cells depletion, correlating with EpCAM+ tumor cell enrichment (Fig. 6E). This evidence concerns the gene EGFR and neoplasm.