TRPC6 and renal fibrosis: Given the kidney's high metabolic demand, kidney fibrosis is believed to be closely linked to hypoxia.[35] Indeed, a lower vessel density in aged mice is associated with accelerated renal fibrosis.[36] Increased VEGF signaling has been shown to prevent age‐associated capillary loss, improve organ perfusion and function, and extend life span.[37] Notably, we found an increase in vascular endothelial cells after TRPC6 blockade.