Bassareo et al. [13] found that elevated EFT and NT-proBNP correlated with diastolic dysfunction in adolescents with Cushing's syndrome, while Altun et al. [17] demonstrated associations between increased EFT, NT-proBNP levels, and arterial stiffness in acute ischemic stroke patients. The gene discussed is NPPB; the disease is Cushing syndrome due to macronodular adrenal hyperplasia.