GPT and obesity due to melanocortin 4 receptor deficiency: Adhering to the 5:2 intermittent fasting diet has been shown to result in weight loss as well as positive changes in anthropometric measures of obesity. It also has the benefit of improving liver enzymes such as ALT, AST, bilirubin, and reducing liver fat, triglycerides, and levels of inflammatory cytokines in patients suffering from non alcoholic fatty liver disease.