Diagnosis is made with a simplified scoring system: ANA or SMA ≥1:40 (1 point), ANA or SMA ≥1:80 or LKM1 ≥1:40 or SLA positive (2 points), serum IgG upper limit of normal (1 point), serum IgG >1.1 x upper limit of normal (2 points), histology compatible (presence of interface hepatitis but not all three features are seen) with AIH (2 points), histology typical (presence of all three major features: interface hepatitis, rosettes, and emperipolesis) of AIH (2 points), negative hepatitis viral markers (2 points). This evidence concerns the gene SMN1 and Hepatitis.