LGALS3 and pemphigus foliaceus: HIF-1 has been reported to induce fibrosis in kidneys [19] and is involved in the pathophysiology of PF [20]. Therefore, we attempted to investigate the role of GIP-10, Gal-3, and HIF-1 in PF-associated COVID-19 and the effectiveness of the Pfizer vaccine against the progression of PF and inflammation by evaluating these biomarkers and estimating if they have a role in the progression of PF.