The keywords and terms used for searching included: "Non-alcoholic Fatty Liver Disease", "Nonalcoholic Steatohepatitis", "metabolic diseases", "Fetuin-A", "FGF21", "Angiopoietin-Like Protein 8", "Retinol-Binding Protein", "Selenoproteins", "Biomarkers", "Clinical markers", and any other relevant MeSH terms. This evidence concerns the gene FGF21 and metabolic dysfunction-associated steatotic liver disease.