Resistance training led to hypermethylation in genes associated with metabolic and hormonal regulation (e.g., WRNIP1, NR2C2AP, DSCR9). Aerobic training resulted in hypermethylation in genes linked to ribosomal function and RNA processing (e.g., RPS27, RPL35A, RIOK2). Epigenetic modifications from both exercise types may enhance genomic stability and metabolic function in PCOS. The gene discussed is RIOK2; the disease is polycystic ovary syndrome.