Hypermethylation and downregulation of miR-10b-5p, miR-127-3p, miR-5189, miR-410-3p, and miR23a-3p were associated with upregulation of phosphatase and tensin homolog (​PTEN)​​​​​, matrix metallopeptidase 13 (MMP13), oxidized low-density lipoprotein receptor 1 (OLR1), tet methylcytosine dioxygenase 3 (TET3), and apoptotic protease-activating factor 1 (APAF1) in PCOS. The gene discussed is PTEN; the disease is polycystic ovary syndrome.