Hypermethylation of miR-10b-5p was linked to ​PTEN overexpression, inhibiting insulin signaling and contributing to IR. Hypermethylation of miR-5189 was linked to increased OLR1, which binds oxidized LDL and promotes its breakdown through cellular uptake of the oxidized low-density lipoprotein (ox-LDL)-OLR1 receptor ligand complex. Hypomethylation of miR-3687 was linked to reduced LDLR, contributing to dyslipidemia. The gene discussed is INS; the disease is metabolic syndrome.