Physical examination showed an unremarkable cardiovascular assessment (normal S1 and S2, no audible murmurs), a clear chest, a soft and non-tender abdomen without organomegaly, and a neurologically intact initial examination. Laboratory investigations revealed: leukocytosis (white blood count (WBC), 15.89 ×109/L, neutrophils, 88.35%), hemoglobin, 15.0 g/dL, thrombocytopenia (platelet count, 41 ×109/L), serum creatinine at 278.8 μmol/L, and elevated C-reactive protein (CRP, 289.33 mg/L). The gene discussed is CRP; the disease is Increased total leukocyte count.