While on the opposite side, in Hashimoto's thyroiditis antibodies against thyroid peroxidase (TPO) and thyroglobulin (TG) - antithyroid peroxidase antibodies (TPOAb), and antithyroglobulin antibodies (TGAb) - leading to destruction of the thyroid tissue and resulting in a hypothyroid state. Here, TPO is linked to Hashimoto thyroiditis.