GSTP1 and cancer: Given that metabolic reprogramming is a hallmark of cancer, supporting tumor survival and progression, our results indicate that GSTP1 plays a broader role in tumor metabolism beyond its canonical function in redox homeostasis and detoxification.20,24,32,33 These findings suggest that GSTP1 loss creates a bioenergetic bottleneck by simultaneously impairing glucose uptake, glycogen metabolism, and fatty acid oxidation, potentially sensitizing PDAC cells to metabolic stress-inducing therapies.