Several classes of GSTP1 inhibitors have been identified, including covalent G-site inhibitors, H-site binders, and natural compounds such as piperlongumine, which has demonstrated anti-tumor activity in PDAC xenograft models.21 These agents inhibit GSTP1 enzymatic activity, disrupt its protein-protein interactions, and promote oxidative stress, thereby enhancing sensitivity to chemotherapeutics. Here, GSTP1 is linked to neoplasm.