Univariable MR Analysis: We found strong evidence that genetically predicted inhibition of VEGFA and RHEB were associated with an increased risk of T2D VEGFA (OR = 2.66, 95% CI: 1.34–3.78, p = 0.001) and RHEB (OR = 2.25, 95% CI: 1.34–3.28, p = 0.001) were associated with an increased risk of T2D. Here, VEGFA is linked to type 2 diabetes mellitus.