NPAS4 and major depressive disorder: There were two notable exceptions: one downregulated gene set was related to stress hormone signaling (GOBP_RESPONSE_TO_MINERALOCORTICOID, strongest leading gene: neuronal PAS domain protein 4 (Npas4), Log2FC = −0.34, p = 0.012, FDR = 0.61), and one of the only upregulated gene sets was derived from a meta‐analysis characterizing the effects of major depressive disorder in the frontal cortex (Gandal_2018_MajorDepressiveDisorder_Upregulated_Cortex, strongest leading gene: follistatin (Fst): Log2FC = 0.14, p = 0.0092, FDR = 0.60).