The upregulated pathways comparing 20K hGH‐V to hGH include metabolic pathways such as the citrate (TCA) cycle (0.600 enrichment score [ES]), adipose tissue‐specific pathways such as adipogenesis (0.502 ES) and thermogenesis (0.402 ES), and neurodegenerative disease pathways such as Parkinson's disease (0.354 ES). This evidence concerns the gene GH1 and neurodegenerative disease.