The main pathways of methylome biomarkers were associated with calcium signalling (CACNA1E, RYR2, RYR3), cancer pathways (DCC, RASSF1, WNT1, CTNNA2), multiple neurodegenerative diseases (WNT1, DNAI1, RYR2, RYR3), immune system disorders and cell adhesion (HLA-DRA, HLA-DRB1, HLA-DRB5). This evidence concerns the gene HLA-DRA and immune system disorder.