Such IVD tests are already available for colon (Cologuard® stool-DNA-based test; Epi proColon® 2.0 test; EarlyTect® CRC assay), cervical (Cervi-M® assay), lung (Epi proLung BL Reflex Assay®), glioblastoma (Therascreen MGMT Pyro Kit), bladder (Bladder EpiCheck®) and other tumours (Refs 94, 95). Here, MGMT is linked to colorectal carcinoma.