The main pathways of methylome biomarkers were associated with calcium signalling (CACNA1E, RYR2, RYR3), cancer pathways (DCC, RASSF1, WNT1, CTNNA2), multiple neurodegenerative diseases (WNT1, DNAI1, RYR2, RYR3), immune system disorders and cell adhesion (HLA-DRA, HLA-DRB1, HLA-DRB5). Here, HLA-DRB5 is linked to cancer.