The main pathways of methylome biomarkers were associated with calcium signalling (CACNA1E, RYR2, RYR3), cancer pathways (DCC, RASSF1, WNT1, CTNNA2), multiple neurodegenerative diseases (WNT1, DNAI1, RYR2, RYR3), immune system disorders and cell adhesion (HLA-DRA, HLA-DRB1, HLA-DRB5). The gene discussed is CTNNA2; the disease is cancer.