Biological enrichment analysis of proteins increased in RHI vs. AD (Fig. 1C) revealed immune pathway enrichment, including TNF-receptor superfamily proteins (TNFRSF1B, TNFRSF1A, TNFRSF11A, TNFRSF14), as well as mitochondrial and phosphatase complex proteins that overlapped with RHI vs. CTL results (MECR, TOMM20, PPP3R1). The gene discussed is PPP3R1; the disease is Alzheimer disease.