Biological enrichment analysis of proteins increased in RHI vs. AD (Fig. 1C) revealed immune pathway enrichment, including TNF-receptor superfamily proteins (TNFRSF1B, TNFRSF1A, TNFRSF11A, TNFRSF14), as well as mitochondrial and phosphatase complex proteins that overlapped with RHI vs. CTL results (MECR, TOMM20, PPP3R1). This evidence concerns the gene TOMM20 and Alzheimer disease.