Notably, none of the plasma modules exhibited significant correlations with GFAP or NfL in RHI cases, whereas M7 cell morphogenesis, M3 neurodevelopment/integrin, and M2 TNF-signaling/cell adhesion significantly correlated with GFAP (M7, M3, M2) and/or NfL (M7, M2) in AD (ρs > 0.35). The gene discussed is NEFL; the disease is Alzheimer disease.