SDC1 and Miyoshi myopathy: Zavidij et al. used single-cell transcriptomics to analyze the CD138 + or CD45 + cell components in the bone marrow of MGUS, SMM, and overt MM patients and reported that the tumor microenvironment began to significantly change from the MGUS stage, with substantial enrichment of NK cells, T cells, and nonclassical monocytes and macrophages [14].