Concurrently, KEGG pathway analysis revealed several critical signaling pathways, including NOD-like receptor signaling, PD-1 checkpoints, and NF-κB signaling pathways related to immune regulation, as well as pathways associated with infectious diseases (e.g., COVID-19, tuberculosis, and Staphylococcus aureus infection) and inflammatory responses. This evidence concerns the gene NFKB1 and infectious disease.