Shi et al. delineated CD73/NT5E as a pivotal downstream effector of the EGFR–MEK axis, driving HPV-negative head and neck squamous cell carcinoma (HNSCC) progression via mechanisms independent of epithelial–mesenchymal transition—namely, tumor invasion and immunosuppression [39]. This evidence concerns the gene EGFR and head and neck squamous cell carcinoma.