Although pharmacologically active in mouse models of TBI and AD [33–35, 37], 3,6′-DTP proved to be short-lived in mouse and human plasma, as evident in Fig. 4A. This thereby, focused our interest on 3-MP—a close analog and potential metabolite which potently binds human cereblon (Fig. 1A, B) but, does not induce the rapid time-dependent downstream degradation of neosubstrates [SALL4 and Aiolos (Fig. 1C1, C2. Here, SALL4 is linked to Alzheimer disease.